Cities have been the focal point for innovation and digitalization strategies for over a decade. From broadband deployment strategies, smart city pilots, projects and programs, to intelligent urban mobility schemes or open data initiatives: cities have led the way. Innovation agendas cannot and must not stop at city limits, however. Smart regional approaches represent the best recipe for digital inclusion, the scaling of relevant innovations, and accessibility to opportunity for all. Five points as to why we must and should consider smart region strategies for our communities.